Sánchez Bayle M, Barrio Pérez M L, Estepa Soto M R, López Verde L
An Esp Pediatr. 1984 Jan;20(1):28-32.
Forty-two cases of children showing recurrent urinary tract infection were treated. Three treatment guides were used: the first group of children were given trimetoprim-sulphametoxazole (TMP-SMZ) only, the second and third ones were treated with TMP-SMZ and alternative nitrofurantoine in the former or nalidixic acid in the latter. After treatment a meaning reduction in frequency of urinary tract infection cases (p less than 0.001) were observed. Best results (lesser percentage of failures and lesser number of urinary tract infection cases per month of observation) were achieved in the second and third groups, probably due to a high percentage of resistance cases against TMP-SMZ found during prophylactic treatment (72.07).
对42例复发性尿路感染患儿进行了治疗。采用了三种治疗方案:第一组患儿仅给予甲氧苄啶-磺胺甲恶唑(TMP-SMZ),第二组和第三组则分别联合使用呋喃妥因或萘啶酸与TMP-SMZ进行治疗。治疗后,观察到尿路感染病例的发生率显著降低(p<0.001)。第二组和第三组取得了最佳效果(失败率较低,每月观察到的尿路感染病例数较少),这可能是由于预防性治疗期间发现对TMP-SMZ耐药的病例比例较高(72.07)。