Sher N
Can Med Assoc J. 1975 Jun 14;112(13 Spec No):16-8.
The cases of 10 children with acute and recurrent infection of the urinary tract are presented. Their ages were between 7 weeks and 9 years. Five of the children had been previously treated with a combination of sulfisoxazole, ampicillin, mandelamine and nitrofurantion and four of these children had "breakthrough" infections. When trimethoprim-sulfamethoxazole was administered twice weekly no further infections were noted in four of these five patients. The second group of five children were started on trimethoprim-sulfamethoxazole from the start of their infection and treatment was continued twice weekly for 5 to 7 months. No recurrence of infection of the urine has been detected up to the present time. It is concluded that treatment with trimethoprim-sulfamethoxazole initiated at the outset of urinary tract infection and twice weekly is a valuable drug in children, provided the organism responsible for the infection is sensitive to this agent.
本文报告了10例急性复发性尿路感染患儿的病例。他们的年龄在7周至9岁之间。其中5名儿童此前曾接受过磺胺异恶唑、氨苄青霉素、乌洛托品和呋喃妥因联合治疗，其中4名儿童出现了“突破性”感染。当每周两次给予甲氧苄啶-磺胺甲恶唑时，这5名患者中的4名未再出现感染。第二组5名儿童从感染开始就使用甲氧苄啶-磺胺甲恶唑治疗，并持续每周两次，共治疗5至7个月。截至目前，未检测到尿路感染复发。结论是，对于尿路感染患儿，只要引起感染的病原体对该药敏感，在感染开始时每周两次使用甲氧苄啶-磺胺甲恶唑治疗是一种有效的药物。
