Boylston A W, Goldin R D, Moore C S
Eur J Immunol. 1984 Mar;14(3):273-5. doi: 10.1002/eji.1830140313.
A monoclonal antibody (mAb) called H1-2D4 which reacts only with the T cell line HPB-ALL and not with other T cell lines, normal or activated peripheral blood cells, B lymphoblasts (B-LCL), or thymocytes has been developed. This mAb cocaps the T3 antigen on HPB-ALL and anti-T3 mAb cocaps the antigen which reacts with H1-2D4. Purified H1-2D4 precipitates a heterodimer from HPB-ALL cells which has components with molecular weights of 51 000 and 39 000. The properties of the molecule recognized by H1-2D4 suggest that it is the HPB-ALL equivalent of the putative human T cell antigen receptor.
一种名为H1-2D4的单克隆抗体已被研制出来，它仅与T细胞系HPB-ALL发生反应，而不与其他T细胞系、正常或活化的外周血细胞、B淋巴母细胞（B-LCL）或胸腺细胞发生反应。这种单克隆抗体与HPB-ALL上的T3抗原共包被，而抗T3单克隆抗体则与与H1-2D4发生反应的抗原共包被。纯化的H1-2D4从HPB-ALL细胞中沉淀出一种异二聚体，其组分的分子量分别为51000和39000。H1-2D4识别的分子特性表明，它相当于假定的人类T细胞抗原受体的HPB-ALL对应物。
