Gusev E I, Arion V Ia, Aristova R A, Ivanokov A N, Tunkel' O I
Zh Nevropatol Psikhiatr Im S S Korsakova. 1984;84(2):168-74.
Forty patients with multiple sclerosis of a differing course, duration and severity were treated in this series. T-activin was employed as an immunocorrective agent (AFT-6 fraction). The immunological status was assessed in all patients observed prior to, during and after the treatment. Good clinical response was noted in patients with a secondary progressive course; the effect of a short course of treatment with T-activin on the state of patients with a prolonged progressive course or at the stage of stabilization in the presence of severe organic symptomatology was less prominent. AFT-6 showed a beneficial effect on the immunological status of patients, largely on the T-immunity system. Following the treatment, most patients displayed the normalization of the total lymphocyte count and of the proportional content of T-cells with their activity rising.
本系列研究对40例病程、持续时间和严重程度各异的多发性硬化症患者进行了治疗。使用T-激活素作为免疫纠正剂(AFT-6组分)。在治疗前、治疗期间和治疗后对所有观察的患者进行免疫状态评估。继发进展型病程的患者出现了良好的临床反应;对于病程较长的进展型患者或存在严重器质性症状处于稳定期的患者,短期使用T-激活素治疗的效果不太显著。AFT-6对患者的免疫状态有有益影响,主要作用于T免疫系统。治疗后,大多数患者的总淋巴细胞计数和T细胞比例含量恢复正常,且活性升高。