László A, Kaiser G
Acta Paediatr Hung. 1983;24(4):323-6.
Typing of HLA A, B and C locus antigens was carried out and the frequency distribution calculated in 32 hemizygous children affected by DMD, in 11 mothers who were either obligatory gene carriers or had increased CPK activity, and in 222 healthy blood donors. For typing peripheral blood lymphocytes and the standard NIH lymphocytotoxicity test were used. The HLA-B7 antigen had a tendency to be more frequent, being 31% in the group of hemizygous children with DMD as against 13.5% in the control group (p less than 0.04). In the gene carrier mothers the frequency of HLA-B7 was 36% (p less than 0.12). In the group of DMD hemizygotes the HLA-Aw24 antigen showed a tendency to higher frequency (p less than 0.05).
对32名患杜氏肌营养不良症（DMD）的半合子儿童、11名必定为基因携带者或肌酸磷酸激酶（CPK）活性升高的母亲以及222名健康献血者进行了人类白细胞抗原（HLA）A、B和C位点抗原分型，并计算了其频率分布。采用外周血淋巴细胞分型及标准的美国国立卫生研究院淋巴细胞毒性试验。HLA - B7抗原在杜氏肌营养不良症半合子儿童组中更常见，占31%，而对照组为13.5%（p＜0.04）。在基因携带者母亲中，HLA - B7的频率为36%（p＜0.12）。在杜氏肌营养不良症半合子组中，HLA - Aw24抗原显示出频率较高的趋势（p＜0.05）。
