Garnett E S, Nahmias C, Firnau G
Can J Neurol Sci. 1984 Feb;11(1 Suppl):174-9. doi: 10.1017/s0317167100046369.
[18F]6-fluoro-L-dopa and positron emission tomography has been used to study intracerebral dopamine distribution in five control subjects and six patients with hemiparkinsonism. In the control subjects striatal, frontal and cingulate accumulations were clearly seen. In addition 18F concentrated in the region of the insula and the parietal lobe. In the patients striatal accumulation 18F was reduced in the contralateral striatum, especially in the putamen. The uniformity of distribution of 18F in the striatum on the side of the parkinsonian signs was also irregular. This finding is consonant with the suggestion that intracerebral compensatory mechanisms prevent the manifestation of intracerebral dopamine deficiency from becoming obvious until a late stage of the disease.
[18F]6-氟-L-多巴与正电子发射断层扫描已被用于研究5名对照受试者和6名偏侧帕金森病患者脑内多巴胺的分布情况。在对照受试者中，纹状体、额叶和扣带回有明显的放射性聚集。此外，18F集中在岛叶和顶叶区域。在患者中，对侧纹状体，尤其是壳核的18F纹状体聚集减少。帕金森病体征侧纹状体内18F分布的均匀性也不规则。这一发现与以下观点一致，即脑内代偿机制可防止脑内多巴胺缺乏的表现直到疾病晚期才变得明显。
