[18F]多巴纹状体摄取的人格相关性：帕金森病正电子发射断层扫描结果
Personality correlates of [18F]dopa striatal uptake: results of positron-emission tomography in Parkinson's disease.
作者信息
Menza M A, Mark M H, Burn D J, Brooks D J
机构信息
Department of Psychiatry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick 08903, USA.
出版信息
J Neuropsychiatry Clin Neurosci. 1995 Spring;7(2):176-9. doi: 10.1176/jnp.7.2.176.
Clinicians have long associated Parkinson's disease (PD) with personality traits such as seriousness and industriousness. In previous studies, patients with PD scored lower than matched orthopedic control subjects on novelty seeking, which is thought to be dopamine dependent. In this pilot study, 6-[18F]fluorodopa ([18F]dopa) uptake in the caudate and putamen was measured by PET in 9 patients with PD. Patients were also rated on three personality traits thought to be related to central monoamine function. Uptake of [18F]dopa in the left caudate, but not in other areas measured, was significantly correlated with novelty seeking. Results suggest that the personality traits long observed in PD patients may be partially mediated by striatal deficits in dopamine.
长期以来，临床医生一直将帕金森病（PD）与诸如认真和勤奋等人格特质联系在一起。在先前的研究中，帕金森病患者在寻求新奇性方面的得分低于匹配的骨科对照受试者，而寻求新奇性被认为是依赖多巴胺的。在这项初步研究中，通过正电子发射断层扫描（PET）测量了9名帕金森病患者尾状核和壳核中6-[18F]氟多巴（[18F]多巴）的摄取情况。患者还根据三种被认为与中枢单胺功能相关的人格特质进行了评分。左尾状核中[18F]多巴的摄取与寻求新奇性显著相关，但在其他测量区域则不然。结果表明，长期以来在帕金森病患者中观察到的人格特质可能部分由纹状体多巴胺缺乏介导。
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