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获得性免疫缺陷综合征中造血祖细胞的体外生长缺陷。

Defective in vitro growth of the hemopoietic progenitor cells in the acquired immunodeficiency syndrome.

作者信息

Stella C C, Ganser A, Hoelzer D

出版信息

J Clin Invest. 1987 Aug;80(2):286-93. doi: 10.1172/JCI113071.

DOI:10.1172/JCI113071

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC442236/

Abstract

In addition to immunologic derangement, hematological abnormalities have been reported in the majority of patients with acquired immunodeficiency syndrome (AIDS). In this study 15 patients with AIDS or AIDS-related complex (ARC) were evaluated for the in vitro growth of hemopoietic progenitor cells. In all patients a significant reduction of growth (mean +/- SEM) of colony-forming unit-granulocyte, erythrocyte, macrophage, (megakaryocyte) (CFU-GEM) (1.2 +/- 0.3), burst-forming unit-erythroid (BFU-E) (17 +/- 10), CFU-megakaryocyte (CFU-Mk) (1.7 +/- 0.6), and CFU-granulocyte-macrophage (CFU-GM) (35 +/- 10) was observed in comparison with normal controls. Depletion of T cells from the bone marrow before culture led to a significant increase in colony growth, which indicated an imbalance of the normally modulating T cell subsets. This increase was reversed by readdition of autologous T cells causing a decrease in colony growth to a degree, dependent on the T4 to T8 ratio. A decreased number of hemopoietic progenitor cells and/or a defective modulation of progenitor cell growth, normally carried out by T lymphocyte subsets, might be the cause of the hematological abnormalities in AIDS patients.

摘要

除了免疫紊乱外，多数获得性免疫缺陷综合征（AIDS）患者还存在血液学异常。在本研究中，对15例艾滋病或艾滋病相关综合征（ARC）患者的造血祖细胞体外生长情况进行了评估。与正常对照组相比，所有患者的集落形成单位-粒细胞、红细胞、巨噬细胞、（巨核细胞）（CFU-GEM）（1.2±0.3）、爆式红系集落形成单位（BFU-E）（17±10）、巨核细胞集落形成单位（CFU-Mk）（1.7±0.6）和粒细胞-巨噬细胞集落形成单位（CFU-GM）（35±10）的生长均显著降低。培养前从骨髓中去除T细胞导致集落生长显著增加，这表明正常调节性T细胞亚群失衡。重新加入自体T细胞可逆转这种增加，导致集落生长程度降低，这取决于T4与T8的比例。造血祖细胞数量减少和/或通常由T淋巴细胞亚群进行的祖细胞生长调节缺陷，可能是艾滋病患者血液学异常的原因。