Staessen J, Bulpitt C J, Fagard R, Joossens J V, Lijnen P, Amery A
Acta Cardiol. 1984;39(1):55-64.
The relationship between contraceptive pill use, urinary sodium and blood pressure was investigated in a random sample of the premenopausal female inhabitants of 2 small Belgian towns. Systolic and diastolic pressure tended to be higher in 58 present pill users (126 +/- 11/75 +/- 9 mm Hg: mean +/- standard deviation) than in 110 women not currently taking the contraceptive pill (123 +/- 11/74 +/- 8 mm Hg). Their urinary sodium excretion averaged 149 +/- 47 and 143 +/- 57 mEq/24 h, respectively. Systolic pressure was positively associated with 24-hour urinary sodium in pill users (r = +0.41; p less than 0.01) and in those not on the pill (r = +0.19; p less than 0.05). This association was independent of age and persisted after adjusting for body weight and pulse rate in pill users, but was no longer apparent in the others when body weight, pulse rate, and age were taken into account. Thus, pill use was associated with an elevation of arterial pressure. In subjects taking the pill a positive association was observed between the urinary sodium excretion and systolic pressure. It is therefore possible that the systolic pressure of pill users becomes responsive to their usual sodium intake.
在比利时两个小镇的绝经前女性居民随机样本中，研究了避孕药使用、尿钠与血压之间的关系。58名当前服用避孕药的女性（收缩压和舒张压分别为126±11/75±9 mmHg：均值±标准差）的收缩压和舒张压往往高于110名未服用避孕药的女性（123±11/74±8 mmHg）。她们的尿钠排泄量平均分别为149±47和143±57 mEq/24小时。服用避孕药的女性中，收缩压与24小时尿钠呈正相关（r = +0.41；p<0.01），未服用避孕药的女性中也是如此（r = +0.19；p<0.05）。这种关联与年龄无关，在服用避孕药的女性中，调整体重和脉搏率后依然存在，但在考虑体重、脉搏率和年龄后，未服用避孕药的女性中这种关联不再明显。因此，服用避孕药与动脉压升高有关。在服用避孕药的受试者中，观察到尿钠排泄与收缩压之间呈正相关。因此，服用避孕药的女性的收缩压可能会对其日常钠摄入量产生反应。
