Cairns V, Keil U, Doering A, Koenig W, Stieber J, Kleinbaum D G
Int J Epidemiol. 1985 Sep;14(3):389-95. doi: 10.1093/ije/14.3.389.
The relationship between blood pressure (BP) and oral contraceptive (OC) use in women has been examined with the data from the Munich Blood Pressure Study (MBS), a cross-sectional study with follow-up of a random sample of 3198 Munich citizens aged 30-69 (response rate 69.3%). Multiple linear and logistic regression analyses were run with BP as the dependent variable and age, OC use, obesity, alcohol consumption, and smoking habit as the independent variables. All second and third order interactions between the independent variables were tested during a backward stepping procedure. OC use appeared as a significant main effect in most of the analyses. The coefficient of the OC variable was about 3 in the linear regression analyses for both systolic BP and diastolic BP, indicating an increase of about 3 mmHg in the systolic and diastolic BP of the OC users. An analysis of the change in BP after one year in relation to change in OC user status has also been made. It was observed that women ceasing to use OC had a clear decrease in BP while those starting to use OC had on average an increase in BP.
利用慕尼黑血压研究（MBS）的数据，对女性血压（BP）与口服避孕药（OC）使用之间的关系进行了研究。MBS是一项横断面研究，对3198名年龄在30 - 69岁的慕尼黑公民随机样本进行了随访（应答率为69.3%）。以血压为因变量，年龄、口服避孕药使用情况、肥胖、饮酒量和吸烟习惯为自变量，进行了多元线性和逻辑回归分析。在向后逐步回归过程中，对自变量之间的所有二阶和三阶交互作用进行了检验。在大多数分析中，口服避孕药的使用表现为显著的主效应。在收缩压和舒张压的线性回归分析中，口服避孕药变量的系数约为3，这表明口服避孕药使用者的收缩压和舒张压平均升高约3 mmHg。还对口服避孕药使用状态变化一年后的血压变化进行了分析。观察到停止使用口服避孕药的女性血压明显下降，而开始使用口服避孕药的女性平均血压升高。
