Burney P G, Neild J E, Twort C H, Chinn S, Jones T D, Mitchell W D, Bateman C, Cameron I R
Department of Community Medicine, United Medical School, Hospital, London.
Thorax. 1989 Jan;44(1):36-41. doi: 10.1136/thx.44.1.36.
The airway response to histamine has been shown to be related to the 24 hour urinary excretion of sodium. To assess whether this relation is likely to represent a direct causal association a randomised double blind crossover trial of slow sodium (80 mmol/day) was compared with placebo in 36 subjects having a low sodium diet. The dose of histamine causing a 20% fall in FEV1 (PD20) was 1.51 doubling doses lower when the men were taking sodium than when they were taking placebo (p less than 0.05). On the basis of PD10 values, the difference in men was 1.66 doubling doses of histamine (p less than 0.05). There was no corresponding effect in women. Regressing PD10 against urinary excretion of electrolytes with data from the two occasions during the trial and the measurements made before the trial showed a significant association with sodium excretion after allowance had been made for any effect associated with potassium or creatinine excretion, the latter being a marker of the completeness of the urine collection. Again there was no corresponding effect among women. These findings are compatible with the differences in regional mortality data for England and Wales, which show a relation between asthma mortality and regional per person purchases of table salt for men but not for women.
气道对组胺的反应已被证明与24小时尿钠排泄有关。为了评估这种关系是否可能代表直接的因果关联，在36名低钠饮食的受试者中进行了一项随机双盲交叉试验，比较了慢效钠（80 mmol/天）与安慰剂的效果。男性服用钠时，使第一秒用力呼气量（FEV1）下降20%的组胺剂量（PD20）比服用安慰剂时低1.51个加倍剂量（p<0.05）。根据PD10值，男性的差异为1.66个组胺加倍剂量（p<0.05）。女性没有相应的效果。用试验期间两次测量的数据以及试验前的测量结果，将PD10与电解质尿排泄量进行回归分析，结果显示，在考虑了与钾或肌酐排泄相关的任何影响后，与钠排泄存在显著关联，后者是尿液收集完整性的一个指标。女性同样没有相应的效果。这些发现与英格兰和威尔士地区死亡率数据的差异相符，该数据显示男性哮喘死亡率与地区人均食盐购买量之间存在关系，而女性则不存在这种关系。
