Fossaluzza V, Sala P G, Tonutti E
Arch Sci Med (Torino). 1983 Jul-Sep;140(3):287-8.
The study of T lymphocyte subpopulations defined by monoclonal antibodies in a group of patients with rheumatoid arthritis and a control group indicated no significant differences in the percentages of total T lymphocytes (OKT3+) or helper-inducer lymphocytes (OKT4+). However there was a significant diminution in suppressor-cytoxic lymphocytes (OKT8+) in patients with active forms of the disease. This diminution led to an increase in the proportion of OKT4+/OKT8+ in patients with active R.A. forms compared to both those in remission and the control group.
在一组类风湿性关节炎患者和一个对照组中,对由单克隆抗体定义的T淋巴细胞亚群进行的研究表明,总T淋巴细胞(OKT3 +)或辅助诱导淋巴细胞(OKT4 +)的百分比没有显著差异。然而,患有活动性疾病的患者中抑制性细胞毒性淋巴细胞(OKT8 +)显著减少。与缓解期患者和对照组相比,这种减少导致活动性类风湿性关节炎患者中OKT4 + /OKT8 +的比例增加。