Pfreundschuh M, Parino G, Gram N, Bröker A, Gause A, Hunstein W
Z Rheumatol. 1983 Nov-Dec;42(6):328-31.
We studied the influence of chrysotherapy on lymphocytes, B-cells, T-cells, and T-lymphocyte subpopulations in 9 rheumatoid-factor-positive female patients with rheumatoid arthritis (RA). After chrysotherapy, the white blood cell count decreased within 1 month; the percentage of lymphocytes, T-cells, and B-cells did not change significantly, nor did the proportion of helper cells as determined by reactivity with monoclonal antibody OKT4. In contrast, the percentage of suppressor T-cells reactive with OKT8 was significantly decreased (p less than 0.05) after 6 months. As a consequence, the helper/suppressor ratio, which was significantly higher than in age- and sex-matched controls (p less than 0.02), showed an even more pronounced deviation from normal values than before therapy. The implications of these findings in regard to a possible immunological mechanism of action of gold and the significance of the disturbance of the "immunoregulatory balance" between helper and suppressor mechanisms for the pathogenesis of RA are discussed.
我们研究了金疗法对9名类风湿因子阳性的类风湿关节炎（RA）女性患者的淋巴细胞、B细胞、T细胞及T淋巴细胞亚群的影响。金疗法后，白细胞计数在1个月内下降；淋巴细胞、T细胞和B细胞的百分比没有显著变化，与单克隆抗体OKT4反应所确定的辅助细胞比例也无显著变化。相比之下，与OKT8反应的抑制性T细胞百分比在6个月后显著降低（p<0.05）。因此，辅助/抑制细胞比值，其显著高于年龄和性别匹配的对照组（p<0.02），显示出比治疗前更明显地偏离正常值。讨论了这些发现对于金可能的免疫作用机制的意义以及辅助和抑制机制之间“免疫调节平衡”紊乱对RA发病机制的重要性。
