含4-氨基苯基链烷酸残基的具有潜在抗炎活性的杂环化合物。V. 2,4-二氢-3H-吡唑-3-酮的衍生物
[Heterocyclic compounds with potential anti-inflammatory activity containing a 4-aminophenylalkanoic acid residue. V. Derivatives of 2,4-dihydro-3H-pyrazole-3-one].
作者信息
Picciòla G, Zavaglio G, Carenini G, Gentili P, Tempra-Gabbiati G
出版信息
Farmaco Sci. 1984 Apr;39(4):371-8.
PMID:6609838
Abstract
The synthesis and pharmacological study of some derivatives of 2,4-dihydro-3H-pyrazol-3-one of general formula (I) are described. The compound in which R = C6H5 and R' = CH3 [2-(4- carboxymethylphenyl )-4-phenyl-5-methyl-2,4- dihydropyrazol -3-one] (MG 18949) proved to have antipyretic activity equal to that of ibuprofen and aminopyrine.
摘要
描述了通式（I）的一些2,4-二氢-3H-吡唑-3-酮衍生物的合成及药理研究。其中R = C6H5且R' = CH3的化合物[2-(4-羧甲基苯基)-4-苯基-5-甲基-2,4-二氢吡唑-3-酮]（MG 18949）被证明具有与布洛芬和氨基比林相当的解热活性。
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