Kaufmann S H, Metelmann C, Diamantstein T, Hahn H
Int J Immunopharmacol. 1984;6(1):81-5. doi: 10.1016/0192-0561(84)90039-0.
4-Hydroperoxycyclophosphamide is a derivative of cyclophosphamide which in vitro is converted into an active metabolite of cyclophosphamide. This compound was used to define the relative susceptibilities of T cells involved in the immune response of mice to the intracellular pathogen, Listeria monocytogenes. L. monocytogenes-specific T cell proliferation and interleukin production in vitro, as well as adoptive protection and delayed-type hypersensitivity in vivo, all proved to be markedly resistant to the action of 4-hydroperoxy-cyclophosphamide, indicating a great homogeneity within the cellular immune response to intracellular pathogens.
4-氢过氧环磷酰胺是环磷酰胺的衍生物，在体外可转化为环磷酰胺的活性代谢产物。该化合物用于确定参与小鼠对细胞内病原体单核细胞增生李斯特菌免疫反应的T细胞的相对敏感性。单核细胞增生李斯特菌特异性T细胞在体外的增殖和白细胞介素产生，以及体内的过继性保护和迟发型超敏反应，均被证明对4-氢过氧环磷酰胺的作用具有明显抗性，表明对细胞内病原体的细胞免疫反应具有高度同质性。
