对细胞内细菌单核细胞增生李斯特菌具有特异性的T细胞系在体外和体内的生物学功能。
Biological functions of t cell lines with specificity for the intracellular bacterium Listeria monocytogenes in vitro and in vivo.
作者信息
Kaufmann S H, Hahn H
出版信息
J Exp Med. 1982 Jun 1;155(6):1754-65. doi: 10.1084/jem.155.6.1754.
Abstract
Peritoneal exudate T lymphocytes from mice immunized with live Listeria monocytogenes were cloned in double-layer soft agar containing heat-killed L. monocytogenes (lower layer) and syngeneic accessory cells (upper layer). Colony-derived T cells were propagated in vitro in the presence of listerial antigen, syngeneic accessory cells, and T cell growth factor. In vitro proliferation, interleukin secretion, and bystander help for B cells of six such T cell lines and several sublines derived from them were found to be antigen dependent and restricted by the H-2IA locus of the major histocompatibility complex. In vivo, these T cell lines conferred delayed-type hypersensitivity to listerial antigen and protection to live L. monocytogenes. It is concluded that different biological functions of acquired antibacterial immunity can be mediated by a single T cell population.
摘要
用活的单核细胞增生李斯特菌免疫的小鼠的腹腔渗出液T淋巴细胞，在含有热灭活的单核细胞增生李斯特菌（下层）和同基因辅助细胞（上层）的双层软琼脂中进行克隆。来自菌落的T细胞在李斯特菌抗原、同基因辅助细胞和T细胞生长因子存在的情况下进行体外增殖。发现六个这样的T细胞系及其衍生的几个亚系的体外增殖、白细胞介素分泌以及对B细胞的旁观者辅助作用是抗原依赖性的，并受主要组织相容性复合体的H-2IA基因座限制。在体内，这些T细胞系赋予对李斯特菌抗原的迟发型超敏反应，并对活的单核细胞增生李斯特菌提供保护。得出的结论是，获得性抗菌免疫的不同生物学功能可由单一T细胞群体介导。
相似文献
1
Biological functions of t cell lines with specificity for the intracellular bacterium Listeria monocytogenes in vitro and in vivo.对细胞内细菌单核细胞增生李斯特菌具有特异性的T细胞系在体外和体内的生物学功能。
J Exp Med. 1982 Jun 1;155(6):1754-65. doi: 10.1084/jem.155.6.1754.
2
3
Anti-bacterial immunity to Listeria monocytogenes in allogeneic bone marrow chimera in mice.小鼠同种异体骨髓嵌合体中对单核细胞增生李斯特菌的抗菌免疫
J Immunol. 1986 Jun 1;136(11):4264-9.
4
Effective protection against Listeria monocytogenes and delayed-type hypersensitivity to listerial antigens depend on cooperation between specific L3T4+ and Lyt 2+ T cells.对单核细胞增生李斯特菌的有效保护以及对李斯特菌抗原的迟发型超敏反应取决于特定的L3T4 +和Lyt 2 + T细胞之间的协作。
Infect Immun. 1985 Apr;48(1):263-6. doi: 10.1128/iai.48.1.263-266.1985.
5
CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo.针对单核细胞增生李斯特菌单个九聚体表位的CD8 + T细胞在体内具有保护作用。
J Exp Med. 1992 Jun 1;175(6):1531-8. doi: 10.1084/jem.175.6.1531.
6
The immunobiological properties expressed in vitro and in vivo of Salmonella enteritidis-induced murine T cell lines.肠炎沙门氏菌诱导的小鼠T细胞系在体内和体外表达的免疫生物学特性。
Kitasato Arch Exp Med. 1990 Sep;63(2-3):107-18.
7
Heat-killed Listeria monocytogenes and L. monocytogenes soluble antigen induce clonable CD4+ T lymphocytes with protective and chemotactic activities in vivo.热灭活的单核细胞增生李斯特菌和单核细胞增生李斯特菌可溶性抗原在体内诱导具有保护和趋化活性的可克隆CD4+ T淋巴细胞。
Infect Immun. 1991 Dec;59(12):4531-9. doi: 10.1128/iai.59.12.4531-4539.1991.
8
Specific Lyt 123 cells are involved in protection against Listeria monocytogenes and in delayed-type hypersensitivity to listerial antigens.特定的Lyt 123细胞参与对单核细胞增生李斯特菌的防御以及对李斯特菌抗原的迟发型超敏反应。
J Exp Med. 1979 Oct 1;150(4):1033-8. doi: 10.1084/jem.150.4.1033.
9
Genetic control of cell-mediated immunity in rats: involvement of RT1.B locus determinants in the proliferative response of T lymphocytes to Listeria antigens.大鼠细胞介导免疫的遗传控制：RT1.B位点决定簇参与T淋巴细胞对李斯特菌抗原的增殖反应。
Infect Immun. 1982 Nov;38(2):521-9. doi: 10.1128/iai.38.2.521-529.1982.
10
Transfer of both protection and delayed-type hypersensitivity against live Listeria is mediated by the CD8+ T cell subset: a study with Listeria-specific T lymphocytes recovered from murine infected liver.针对活的李斯特菌的保护性免疫和迟发型超敏反应的传递均由CD8 + T细胞亚群介导：一项对从小鼠感染肝脏中分离出的李斯特菌特异性T淋巴细胞的研究。
Int Immunol. 1992 May;4(5):591-8. doi: 10.1093/intimm/4.5.591.
引用本文的文献
1
Murine T-cell clones against Entamoeba histolytica: in vivo and in vitro characterization.针对溶组织内阿米巴的小鼠T细胞克隆：体内和体外特性研究
Immunology. 1989 Jan;66(1):76-82.
2
gp96-peptide vaccination of mice against intracellular bacteria.用gp96肽对小鼠进行细胞内细菌疫苗接种。
Infect Immun. 2001 Jun;69(6):4164-7. doi: 10.1128/IAI.69.6.4164-4167.2001.
3
Disruption of the cellular inflammatory response to Listeria monocytogenes infection in mice with disruptions in targeted genes.在靶向基因发生破坏的小鼠中，细胞对单核细胞增生李斯特菌感染的炎症反应受到破坏。
Infect Immun. 1998 May;66(5):2284-9. doi: 10.1128/IAI.66.5.2284-2289.1998.
4
Activation of CD8 T cells with specificity for mycobacterial heat shock protein 60 in Mycobacterium bovis bacillus Calmette-Guérin-vaccinated mice.在卡介苗接种的牛分枝杆菌小鼠中，对分枝杆菌热休克蛋白60具有特异性的CD8 T细胞的激活。
Infect Immun. 1997 Sep;65(9):3947-50. doi: 10.1128/iai.65.9.3947-3950.1997.
5
CD95 (Fas) may control the expansion of activated T cells after elimination of bacteria in murine listeriosis.CD95（Fas）可能在小鼠李斯特菌病中细菌清除后控制活化T细胞的扩增。
Infect Immun. 1997 May;65(5):1883-91. doi: 10.1128/iai.65.5.1883-1891.1997.
6
Superior efficacy of secreted over somatic antigen display in recombinant Salmonella vaccine induced protection against listeriosis.重组沙门氏菌疫苗中分泌型抗原展示相对于体细胞抗原展示在诱导抗李斯特菌病保护方面具有更高的效力。
Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1458-63. doi: 10.1073/pnas.93.4.1458.
7
Listeria monocytogenes-induced gamma interferon secretion by intestinal intraepithelial gamma/delta T lymphocytes.单核细胞增生李斯特菌诱导肠道上皮γ/δ T淋巴细胞分泌γ干扰素
Infect Immun. 1993 May;61(5):2154-61. doi: 10.1128/iai.61.5.2154-2161.1993.
8
Infection with Listeria monocytogenes impairs sialic acid addition to host cell glycoproteins.感染单核细胞增生李斯特菌会损害宿主细胞糖蛋白上唾液酸的添加。
J Exp Med. 1994 Dec 1;180(6):2137-45. doi: 10.1084/jem.180.6.2137.
9
Human T-cell recognition of Listeria monocytogenes: recognition of listeriolysin O by TcR alpha beta + and TcR gamma delta + T cells.人类T细胞对单核细胞增生李斯特菌的识别：TcRαβ⁺和TcRγδ⁺ T细胞对李斯特菌溶血素O的识别
Infect Immun. 1995 Jun;63(6):2288-94. doi: 10.1128/iai.63.6.2288-2294.1995.
10
Regulatory interactions between macrophages and T-cell subsets in Listeria monocytogenes-specific T-cell activation.单核细胞增生李斯特菌特异性T细胞激活过程中巨噬细胞与T细胞亚群之间的调节相互作用。
Infect Immun. 1982 Dec;38(3):907-13. doi: 10.1128/iai.38.3.907-913.1982.
本文引用的文献
1
Cellular resistance to infection.细胞抗感染能力。
J Exp Med. 1962 Sep 1;116(3):381-406. doi: 10.1084/jem.116.3.381.
2
T cells may express multiple activities: specific allohelp, cytolysis, and delayed-type hypersensitivity are expressed by a cloned T-cell line.T细胞可能表现出多种活性：一种克隆的T细胞系可表现出特异性同种辅助、细胞溶解和迟发型超敏反应。
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4540-3. doi: 10.1073/pnas.78.7.4540.
3
T-cell-dependent B-cell stimulation is H-2 restricted and antigen dependent only at the resting B-cell level.T细胞依赖性B细胞刺激是H-2限制性的，并且仅在静止B细胞水平上依赖抗原。
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1612-6. doi: 10.1073/pnas.77.3.1612.
4
Selective reconstitution of nude mice with long-term cultured and cloned specific helper T cells.用长期培养和克隆的特异性辅助性T细胞对裸鼠进行选择性重建。
Nature. 1980 Feb 21;283(5749):780-1. doi: 10.1038/283780a0.
5
Antigen-specific T-helper cells stimulate H-2-compatible and H-2-incompatible B-cell blasts polyclonally.抗原特异性辅助性T细胞可多克隆地刺激H-2相容和H-2不相容的B细胞母细胞。
J Exp Med. 1980 Jan 1;151(1):194-203. doi: 10.1084/jem.151.1.194.
6
The role of cell-mediated immunity in bacterial infections.细胞介导的免疫在细菌感染中的作用。
Rev Infect Dis. 1981 Nov-Dec;3(6):1221-50. doi: 10.1093/clinids/3.6.1221.
7
T cell-dependent activation of resting B cells: requirement for both nonspecific unrestricted and antigen-specific Ia-restricted soluble factors.静止B细胞的T细胞依赖性激活：对非特异性无限制和抗原特异性Ia限制可溶性因子的需求。
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2497-501. doi: 10.1073/pnas.78.4.2497.
8
9
Clonal induction of helper T cells: conversion of specific signals into nonspecific signals.辅助性T细胞的克隆诱导：将特异性信号转化为非特异性信号。
Int Arch Allergy Appl Immunol. 1980;61(2):227-37. doi: 10.1159/000232437.
10
Recent studies on acquired immunity in tuberculosis.近期关于结核病获得性免疫的研究。
Curr Top Microbiol Immunol. 1969;48:129-78. doi: 10.1007/978-3-642-46163-7_6.
Zotero 插件