Vos O, Roos-Verhey W S
Int J Radiat Biol Relat Stud Phys Chem Med. 1984 May;45(5):479-86. doi: 10.1080/09553008414550681.
A number of compounds were studied that protected mice against LD50/30 after X-irradiation. For three compounds (WR 109342, WR 158490 and WR 159243) dose reduction factors between 1.7 and 1.8 were obtained after oral administration. Blood taken from mice that had been treated with these protective compounds provided virtually no protection of HeLa cells in vitro, whereas when blood from cysteamine treated mice was tested in vitro, protection could be demonstrated. This may indicate different mechanisms of action.
研究了多种化合物，这些化合物在X射线照射后可保护小鼠免受半数致死剂量（LD50）的30%剂量影响。对于三种化合物（WR 109342、WR 158490和WR 159243），口服给药后获得了1.7至1.8之间的剂量降低系数。从用这些保护化合物处理过的小鼠身上采集的血液在体外几乎不能保护HeLa细胞，而当测试半胱胺处理过的小鼠的血液时，在体外可证明有保护作用。这可能表明作用机制不同。
