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对预先用辐射防护物质处理过的小鼠进行照射。一项病理学和血液学研究。

Irradiation of mice pre-treated with radiation protective substances. A pathologic and haematologic investigation.

作者信息

Ousavaplangchai L, Rönnbäck C, Rehbinder C, Nilsson A

出版信息

Acta Radiol Oncol Radiat Phys Biol. 1978;17(2):125-37. doi: 10.3109/02841867809127913.

DOI:10.3109/02841867809127913
PMID:696405
Abstract

CBA male mice were irradiated with single doses of 7.1, 8.6, 10.0, 11.4 or 12.8 Gy, respectively. A protective substance, 2,2-Dithiobis(N-[(1-adamantyl)methyl]acetamidine)-dihydrochloride, here called S-75, was administered orally, 45 min before start of irradiation. Cysteamine-HCl was used as a reference protective substance. Pathologic and haematologic examination of irradiated animals was performed. Cysteamine had somewhat better protective abilities than did S-75, but the latter had some other properties which indicate its possible usefulness in practice.

摘要

分别用7.1、8.6、10.0、11.4或12.8戈瑞的单剂量对CBA雄性小鼠进行辐照。一种保护物质2,2-二硫代双(N-[(1-金刚烷基)甲基]乙脒)二盐酸盐,此处称为S-75,在辐照开始前45分钟口服给药。盐酸半胱胺用作参考保护物质。对辐照后的动物进行了病理和血液学检查。半胱胺的保护能力比S-75稍好,但后者具有一些其他特性,表明其在实际应用中可能有用。

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