Posnett D N, Marboe C C, Knowles D M, Jaffe E A, Kunkel H G
J Immunol. 1984 Jun;132(6):2700-2.
A monoclonal antibody (alpha HC1) raised against HCL cells reacted specifically with HCL cells and not with other normal or leukemic B cell types. It also reacted with BC and with vascular EC. One case of Kaposi's sarcoma, a tumor thought to derive from EC, was also stained by this antibody. Sinusoidal cells of liver and spleen and EC in the brain did not stain with alpha HC1, but EC from all other tissues and EC in culture were positive. Because the exact normal cell equivalent of the leukemic hairy cell is unknown, similarities in phenotype and function between EC and hairy cells are of particular interest.
一种针对毛细胞白血病（HCL）细胞产生的单克隆抗体（αHC1）与HCL细胞发生特异性反应，而不与其他正常或白血病性B细胞类型反应。它也与基底细胞（BC）和血管内皮细胞（EC）发生反应。一例被认为起源于内皮细胞的卡波西肉瘤也被该抗体染色。肝脏和脾脏的窦状细胞以及脑中的内皮细胞不被αHC1染色，但来自所有其他组织的内皮细胞和培养中的内皮细胞呈阳性。由于白血病毛细胞确切的正常细胞对应物尚不清楚，内皮细胞和毛细胞在表型和功能上的相似性特别令人感兴趣。
