Ikeda Y, Kawakami K, Sato I, Tajima S, Ito K, Nose T
J Pharmacobiodyn. 1984 Jan;7(1):15-20. doi: 10.1248/bpb1978.7.15.
The effect of cianidanol (KB-53) on the mouse cytotoxic-T-lymphocyte (CTL) activity of the splenic cells was investigated. The CTL activity of the splenic cells prepared from C3H/He, DBA/2 and CBA strain mice which had been sensitized with EL-4 cells were recognized markedly 11 d after the sensitization. The CTL activity showed an antigen specificity. KB-53, in a dose range of 125-1000 mg/kg, augmented the mouse CTL activity in a dose-dependent manner by oral administration once daily for 5 d beginning immediately after the sensitization. This CTL activity disappeared with treatment of the splenic cell with anti-thy-l serum and normal guinea pig serum, therefore, it was confirmed that the cytotoxic activity of the splenic cells which were prepared from the mice sensitized with EL-4 cells depended on the T-cell activity.
研究了西尼达醇（KB - 53）对小鼠脾细胞细胞毒性T淋巴细胞（CTL）活性的影响。用EL - 4细胞致敏的C3H/He、DBA/2和CBA品系小鼠制备的脾细胞，在致敏后11天其CTL活性得到显著识别。CTL活性表现出抗原特异性。在致敏后立即开始，以125 - 1000 mg/kg的剂量范围，每天口服给药5天，KB - 53以剂量依赖性方式增强小鼠CTL活性。用抗Thy - 1血清和正常豚鼠血清处理脾细胞后，这种CTL活性消失，因此，证实了用EL - 4细胞致敏的小鼠制备的脾细胞的细胞毒性活性依赖于T细胞活性。
