Ikeda Y, Kawakami K, Sato I, Tajima S, Ito K, Nose T
J Pharmacobiodyn. 1984 Jan;7(1):21-3. doi: 10.1248/bpb1978.7.21.
The effect of cianidanol (KB-53) on the mouse natural killer (NK) cell activity of the splenic cells was investigated using YAC-1 cells as target cells. The oral administration of KB-53 at a dose of 500 mg/kg augmented significantly the NK cell activity. The activity was observed maximally 3 d after the administration, and significant difference from the control was observed even at 7 d after the administration of KB-53. The oral administration of KB-53, at a dose range of 125-500 mg/kg, augmented the NK cell activity in a dose-dependent manner at 3 d after the administration.
以YAC-1细胞为靶细胞，研究了西阿尼醇（KB-53）对小鼠脾细胞自然杀伤（NK）细胞活性的影响。以500mg/kg的剂量口服KB-53可显著增强NK细胞活性。给药后3天观察到活性最高，即使在给予KB-53后7天，与对照组相比仍有显著差异。在125-500mg/kg的剂量范围内口服KB-53，给药后3天可剂量依赖性地增强NK细胞活性。
