类风湿关节炎家族中的血清学异常，包括常见独特型PR4 。
Serological abnormalities, including common idiotype PR4, in families with rheumatoid arthritis.
作者信息
Youinou P, Williams W, Le Goff P, Tuaillon N, Jouquan J, Muller S, Isenberg D A
机构信息
Department of Rheumatology, Brest University Medical School.
出版信息
Ann Rheum Dis. 1989 Nov;48(11):898-904. doi: 10.1136/ard.48.11.898.
A broad range of autoreactivity among a group of 12 French patients with rheumatoid arthritis (RA) and 58 of their healthy first degree relatives has been identified. Over 15% of the patients were found to have antibodies to ssDNA, histone H1, H2A, and H2bB. Among the relatives, IgG and IgM rheumatoid factor and antibodies to ssDNA, H2A, and H4 were present in more than 10%. Even more remarkable, a common anti-DNA antibody idiotype designated PR4, known to be present in 70% of patients with systemic lupus erythematosus (SLE), was found in approximately 30% of both patients with RA and their healthy relatives. This is quite different from its lack of increased expression in relatives of patients with SLE and suggests that in the family members of those with RA a particular combination of environmental influence on germline gene expression is responsible.
在一组12名法国类风湿性关节炎（RA）患者及其58名健康的一级亲属中，已发现广泛的自身反应性。超过15%的患者被发现有抗单链DNA、组蛋白H1、H2A和H2bB的抗体。在亲属中，IgG和IgM类风湿因子以及抗单链DNA、H2A和H4的抗体的存在率超过10%。更值得注意的是，一种名为PR4的常见抗DNA抗体独特型，已知在70%的系统性红斑狼疮（SLE）患者中存在，在约30%的RA患者及其健康亲属中均被发现。这与它在SLE患者亲属中没有表达增加形成了鲜明对比，表明在RA患者的家庭成员中，环境对种系基因表达的特定组合影响起到了作用。
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