促分泌素诱导大鼠外分泌胰腺中肌醇磷酸的形成。对肌醇三磷酸信使作用的启示。
Secretagogue-induced formation of inositol phosphates in rat exocrine pancreas. Implications for a messenger role for inositol trisphosphate.
作者信息
Rubin R P, Godfrey P P, Chapman D A, Putney J W
出版信息
Biochem J. 1984 Apr 15;219(2):655-9. doi: 10.1042/bj2190655.
Abstract
The formation of inositol phosphates in response to secretagogues was studied in rat pancreatic acini preincubated with [3H]inositol. Carbachol caused rapid increases in radioactive inositol phosphate, inositol bisphosphate and inositol trisphosphate . This effect was blocked by atropine, and also elicited by caerulein, but not by ionomycin or phorbol dibutyrate. Thus phospholipase C-mediated breakdown of polyphosphoinositides, with the resulting formation of inositol phosphates, may be an early step in the stimulus-secretion coupling pathway in exocrine pancreas. Inositol trisphosphate may function as a second messenger in the exocrine pancreas, coupling receptor activation to internal Ca2+ release.
摘要
用[3H]肌醇预孵育大鼠胰腺腺泡后，研究了其对促分泌剂产生反应时肌醇磷酸的形成。卡巴胆碱可使放射性肌醇磷酸、肌醇二磷酸和肌醇三磷酸迅速增加。这种作用被阿托品阻断，也可被雨蛙肽引发，但离子霉素或佛波醇二丁酸酯不能引发。因此，磷脂酶C介导的多磷酸肌醇分解，以及由此产生的肌醇磷酸形成，可能是外分泌胰腺刺激-分泌偶联途径中的早期步骤。肌醇三磷酸可能作为外分泌胰腺中的第二信使，将受体激活与细胞内Ca2+释放偶联起来。
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