Barr R E, Ackmann J J, Harrington G J, Varma R R, Lewis J D, Casper J T
Electroencephalogr Clin Neurophysiol. 1977 Apr;42(4):466-79. doi: 10.1016/0013-4694(77)90210-3.
The EEGs of 7 children with Reye's syndrome (fatty liver and encephalopathy) were continuously recorded on magnetic tape for times ranging from 12 to 80 h. During these times the major therapy consisted of exchange blood transfusions. The tapes were automatically processed on a LINC-8 computer using a peak-detection algorithm. The main parameters investigated were the delta and theta indices, the mean EEG frequency, the mean peak-to-peak amplitude, and the frequency versus amplitude characteristics of the delta waves. In 5 patients who responded to therapy, a marked decrease in the delta activity and an increase in mean frequency were noted subsequent to exchange transfusions. In all 5 cases the delta waves exhibited a similar pattern of decreasing amplitude and increasing frequency following therapy. However, in 2 patients with a fatal outcome, no favorable EEG response was observed during treatment, and a simultaneous decline in both delta frequency and delta amplitude was noted as the clinical condition worsened. The results of this study indicate that continuous EEG monitoring in Reye's syndrome may be an important clinical adjunct in evaluating the effectiveness of exchange transfusion therapy and in signaling the need for further treatment.
对7例患有瑞氏综合征（脂肪肝和脑病）的儿童的脑电图进行了连续12至80小时的磁带记录。在此期间，主要治疗方法为换血输血。使用峰值检测算法在LINC - 8计算机上对磁带进行自动处理。所研究的主要参数包括δ波和θ波指数、脑电图平均频率、平均峰峰值幅度以及δ波的频率与幅度特征。在5例对治疗有反应的患者中，换血输血后观察到δ波活动显著减少，平均频率增加。在所有5例病例中，治疗后δ波均呈现出幅度降低、频率增加的相似模式。然而，在2例预后不良的患者中，治疗期间未观察到脑电图有良好反应，且随着临床病情恶化，δ波频率和δ波幅度同时下降。本研究结果表明，瑞氏综合征中的连续脑电图监测可能是评估换血输血治疗效果以及提示是否需要进一步治疗的重要临床辅助手段。
