Yamada T, Tucker R P, Kooi K A
Electroencephalogr Clin Neurophysiol. 1976 Jun;40(6):645-53. doi: 10.1016/0013-4694(76)90139-5.
Of ten patients with Reye's syndrome, there were five with stage II or III coma where EEGs revealed 14 c/sec positive bursts in a background of diffuse delta waves. Positive bursts disappeared upon EEG improvement in two survivors and when the EEG became nearly isoelectric in two other patients. Although 14 and 6 c/sec positive bursts are seen commonly during sleep in normal young persons, their occurence in association with diffuse delta waves in acutely ill, comatose patients has been rarely reported. It is not certain whether the present findings should be regarded as selective preservation of a type of sleep pattern or whether there are special factors that enhance positive bursts in stage II or III coma of Reye's syndrome.
在10例瑞氏综合征患者中，有5例处于II期或III期昏迷，脑电图显示在弥漫性δ波背景下有14次/秒的正相棘波爆发。两名幸存者脑电图改善时正相棘波爆发消失，另外两名患者脑电图接近等电位时正相棘波爆发也消失。虽然正常年轻人睡眠时常见14次/秒和6次/秒的正相棘波爆发，但在急性病昏迷患者中，其与弥漫性δ波同时出现的情况鲜有报道。目前的发现究竟应被视为一种睡眠模式的选择性保留，还是存在特殊因素增强了瑞氏综合征II期或III期昏迷时的正相棘波爆发，尚不确定。
