Nilsson E, Meretoja O A, Neuvonen P
Anesth Analg. 1983 Oct;62(10):885-8.
Hemodynamic responses to physostigmine were evaluated in eight patients with coma due to overdose with mainly anticholinergic drugs (AC) and in five patients with coma due to overdose with nonanticholinergic drugs (NAC). After correction of hypovolemia, but before administration of physostigmine, AC patients had significantly lower systemic vascular resistances, slightly higher cardiac outputs, and lower mean arterial pressures than NAC patients. Physostigmine produced negligible hemodynamic and, as expected, negligible neurological changes in NAC patients. In AC patients physostigmine produced, also as expected, improved consciousness and in addition significantly increased mean arterial pressure, cardiac output, and cardiac work without significantly affecting systemic vascular resistance.
对8例主要因抗胆碱能药物（AC）过量导致昏迷的患者和5例因非抗胆碱能药物（NAC）过量导致昏迷的患者评估了毒扁豆碱的血流动力学反应。在纠正血容量不足后，但在给予毒扁豆碱之前，AC组患者的全身血管阻力显著低于NAC组患者，心输出量略高，平均动脉压较低。毒扁豆碱对NAC组患者的血流动力学影响可忽略不计，并且正如预期的那样，对神经学的影响也可忽略不计。在AC组患者中，正如预期的那样，毒扁豆碱使意识得到改善，此外还显著提高了平均动脉压、心输出量和心脏作功，而对全身血管阻力没有显著影响。
