[Cellular actions of inhibitors of chemical carcinogenesis: modifications of syntheses of prostaglandins and differentiation of myeloid leukemia cells].

Although various substances are involved in modification of chemical carcinogenesis, prostaglandins have been known to play an important role in the modification of the carcinogenesis. In this report, recent advances in the modification of chemical carcinogenesis by prostaglandins are reviewed. In addition, recent experimental results on the modification of cell differentiation by prostaglandins and some inhibitors of chemical carcinogenesis are described. Some inhibitors of chemical carcinogenesis are found to modify differentiation of mouse myeloid leukemia cells (M1) into macrophages and granulocytes by perturbation of syntheses of prostaglandins. These experimental results suggest that the modification by the inhibitors of carcinogenesis of differentiation of cells by perturbation of syntheses of prostaglandins is involved in the mechanisms of inhibition of chemical carcinogenesis.