新生儿对乙酰氨基酚中毒：换血治疗
Neonatal paracetamol poisoning: treatment by exchange transfusion.
作者信息
Lederman S, Fysh W J, Tredger M, Gamsu H R
出版信息
Arch Dis Child. 1983 Aug;58(8):631-3. doi: 10.1136/adc.58.8.631.
Abstract
The metabolism and excretion of paracetamol was studied in an infant of 29 weeks' gestation who was exposed to the drug when his mother ingested 32.5 g 16 hours before delivery. We have confirmed that sulphation is the major pathway and that the mixed function oxidase system is sufficiently active at this gestational age to produce hepatotoxic metabolic products. As most of the recognised drug treatments for paracetamol poisoning seemed unsuitable in this case, the infant was treated with exchange transfusions.
摘要
对一名孕29周的婴儿进行了对乙酰氨基酚的代谢和排泄研究，该婴儿在其母亲于分娩前16小时摄入32.5克该药物时接触到了该药物。我们已经证实，硫酸化是主要途径，并且混合功能氧化酶系统在这个孕周时活性足够高，能够产生肝毒性代谢产物。由于在这种情况下，大多数公认的对乙酰氨基酚中毒药物治疗方法似乎都不合适，该婴儿接受了换血治疗。
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Neonatal paracetamol poisoning: treatment by exchange transfusion.新生儿对乙酰氨基酚中毒：换血治疗
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本文引用的文献
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Plasma-paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage.对乙酰氨基酚过量患者的血浆对乙酰氨基酚半衰期与肝坏死
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