发生过敏反应的大鼠眼部组织中肥大细胞的超微结构
Ultrastructure of mast cells in rat ocular tissue undergoing anaphylaxis.
作者信息
Henriquez A S, Bloch K J, Kenyon K R, Baird R S, Hanninen L A, Allansmith M R
出版信息
Arch Ophthalmol. 1983 Sep;101(9):1439-46. doi: 10.1001/archopht.1983.01040020441023.
In a study of ocular tissues undergoing anaphylaxis, in uninjected rats most mast cells contained electron-dense granules with no discernible internal structure. A few cells showed varying degrees of swelling of the matrix granules. In rats injected with normal rabbit serum, more mast cells showed swelling of the granule matrix and a few showed extensive swelling of nearly all granules. Mast cells from rats undergoing anaphylaxis by either anti-IgE or antigen injection showed membrane and granule alterations: extensive dendritic processes, fusion of granule membranes, fusion between granule and plasma membranes, and disruption of plasma membranes. Communication was established between the exterior of the cell and contents of individual granules of cisternae formed by several fused granules. The matrix of nearly all granules was extensively swollen.
在一项关于经历过敏反应的眼部组织的研究中，未注射的大鼠中，大多数肥大细胞含有电子致密颗粒，其内部结构难以辨别。少数细胞显示出基质颗粒不同程度的肿胀。在注射了正常兔血清的大鼠中，更多的肥大细胞显示出颗粒基质肿胀，少数细胞几乎所有颗粒都出现广泛肿胀。通过抗IgE或抗原注射经历过敏反应的大鼠的肥大细胞显示出膜和颗粒改变：广泛的树突状突起、颗粒膜融合、颗粒与质膜融合以及质膜破裂。在细胞外部与由几个融合颗粒形成的池的单个颗粒内容物之间建立了连通。几乎所有颗粒的基质都广泛肿胀。
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