Sanders C L, Rhoads K, Mahaffey J A
Environ Res. 1983 Oct;32(1):188-98. doi: 10.1016/0013-9351(83)90205-0.
The effects of Ritzville sandy loam soil and Mount St. Helens volcanic ash particles on the lung and mediastinal lymph nodes of Fischer rats were studied about 400 days after intratracheal instillation. A total of 22 or 77 mg of soil or ash was given in two or seven equally divided, consecutive, weekly intervals as a suspension in 0.5 ml saline. Significantly elevated levels of lipid-phosphorus and protein were found in lung lavages of rats given ash compared to those given soil. An enhanced histological degree of granulomatous reactivity, lipoproteinosis, fibrosis, and bronchiolar hyperplasia was seen in ash-exposed rats as compared to soil-exposed rats. Mediastinal lymph nodes of ash-exposed rats were 8-18 times larger than those of soil-exposed rats due to abundant cellular microgranuloma formation and early fibrosis. Mount St. Helens volcanic ash is apparently more biologically reactive than soil particles commonly found in eastern Washington.
在气管内滴注约400天后，研究了里兹维尔砂壤土和圣海伦斯火山灰颗粒对费希尔大鼠肺和纵隔淋巴结的影响。将总共22毫克或77毫克的土壤或火山灰以0.5毫升生理盐水的悬浮液形式，分两次或七次等份、连续、每周间隔给予。与给予土壤的大鼠相比，给予火山灰的大鼠肺灌洗中脂质磷和蛋白质水平显著升高。与暴露于土壤的大鼠相比，暴露于火山灰的大鼠出现了组织学上肉芽肿反应、脂蛋白沉着症、纤维化和细支气管增生程度增强的情况。由于大量细胞微肉芽肿形成和早期纤维化，暴露于火山灰的大鼠纵隔淋巴结比暴露于土壤的大鼠大8至18倍。圣海伦斯火山灰显然比华盛顿东部常见的土壤颗粒具有更高的生物反应性。
