新多烯抗生素阿霉素的生物学特性

Biological properties of acmycin, a new polyene antibiotic.

作者信息

Chakrabarti S, Chandra A L

出版信息

Folia Microbiol (Praha). 1983;28(4):282-6. doi: 10.1007/BF02879559.

Abstract

Acmycin, a new polyene antibiotic, was fungistatic at low and fungicidal at high concentrations. It produced malformations in conidia of Helminthosporium oryzae and Curvularia lunata and caused leakage of yeast cells. Acmycin was fairly nontoxic to germinating seeds. The intravenous LD50 was 300-400 and intraperitoneal maximum tolerated dose 100-500 mg/kg body mass of mice.

摘要

阿霉素是一种新型多烯抗生素，在低浓度时具有抑菌作用，高浓度时具有杀菌作用。它能使稻瘟病菌和新月弯孢霉的分生孢子产生畸形，并导致酵母细胞渗漏。阿霉素对萌发的种子毒性相当低。小鼠静脉注射的半数致死量为300 - 400，腹腔注射的最大耐受剂量为100 - 500毫克/千克体重。