表皮酮 A，一种广谱抗真菌化合物，由 ICMP 19927 产生。

School of Biological Sciences, University of Auckland, 3A Symonds Street, 1010 Auckland, New Zealand.

School of Chemical Sciences, University of Auckland, 23 Symonds Street, 1010 Auckland, New Zealand.

Molecules. 2020 Dec 18;25(24):5997. doi: 10.3390/molecules25245997.

We have isolated a filamentous fungus that actively secretes a pigmented exudate when growing on agar plates. The fungus was identified as being a strain of . The fungal exudate presented strong antifungal activity against both yeasts and filamentous fungi, and inhibited the germination of fungal spores. The chemical characterization of the exudate showed that the pigmented molecule presenting antifungal activity is the disalt of epipyrone A-a water-soluble polyene metabolite with a molecular mass of 612.29 and maximal UV-Vis absorbance at 428 nm. This antifungal compound showed excellent stability to different temperatures and neutral to alkaline pH.

我们从在琼脂平板上生长时会主动分泌有色渗出物的丝状真菌中分离到一种真菌。该真菌被鉴定为. 真菌渗出物对酵母和丝状真菌均具有强烈的抗真菌活性，并抑制真菌孢子的萌发。渗出物的化学特征表明，具有抗真菌活性的色素分子是 epipyrone A-a 的二钠盐-一种水溶性多烯代谢物，分子量为 612.29，在 428nm 处具有最大的紫外可见吸收。该抗真菌化合物对不同温度和中性至碱性 pH 值具有极好的稳定性。