Southren A L, Gordon G G, Munnangi P R, Vittek J, Schwartz J, Monder C, Dunn M W, Weinstein B I
Invest Ophthalmol Vis Sci. 1983 Oct;24(10):1413-7.
Cells cultured from trabecular meshwork specimens obtained from patients with primary open angle glaucoma (TMPOAG cells) exhibited two major differences in cortisol-metabolizing enzymes when compared with similar cells from nonglaucomatous patients. One is a marked increase (greater than 100-fold) in delta 4-reductase activity and the other is a decrease (4-fold) in 3-oxidoreductase activity. Peripheral lymphocytes from one of these patients as well as from five additional patients with POAG, did not show these abnormalities, indicating that the defects are not found in all cortisol-metabolizing cells. The abnormal metabolism of cortisol by TMPOAG cells may be of significance in the pathogenesis of POAG.
从原发性开角型青光眼患者获取的小梁网标本培养的细胞（TMPOAG细胞）与非青光眼患者的类似细胞相比，在皮质醇代谢酶方面表现出两个主要差异。一个是δ4-还原酶活性显著增加（超过100倍），另一个是3-氧化还原酶活性降低（4倍）。这些患者中的一名患者以及另外五名原发性开角型青光眼患者的外周淋巴细胞未显示出这些异常，表明并非所有皮质醇代谢细胞都存在缺陷。TMPOAG细胞对皮质醇的异常代谢可能在原发性开角型青光眼的发病机制中具有重要意义。
