Feigenbaum J J, Yanai J, Klawans H L
J Neural Transm. 1983;57(1-2):27-37. doi: 10.1007/BF01250045.
The effect of dopaminergic and serotonergic agonists and antagonists on quipazine induced locomotor activity was investigated in rats. Though quipazine is generally considered to be a relatively pure serotonergic agonist, its effects on locomotor activity were inhibited by small doses of a centrally acting DA receptor blocking agent (haloperidol), while three different serotonergic (5-HT) antagonists were without effect on this behavior. Moreover, quipazine induced locomotor activity was markedly inhibited by the 5-HT substrate 5-hydroxytryptophan. The data suggest that quipazine induced locomotor activity primarily involves dopaminergic mechanisms, with 5-HT playing either no role in stimulating this behavior, or a subsidiary one, requiring intact central dopaminergic receptors for its expression.
研究了多巴胺能和5-羟色胺能激动剂及拮抗剂对大鼠中由喹哌嗪诱导的运动活性的影响。尽管喹哌嗪通常被认为是一种相对纯的5-羟色胺能激动剂，但其对运动活性的作用可被小剂量的中枢作用性多巴胺受体阻断剂（氟哌啶醇）所抑制，而三种不同的5-羟色胺能（5-HT）拮抗剂对此行为无影响。此外，喹哌嗪诱导的运动活性被5-HT底物5-羟色氨酸显著抑制。这些数据表明，喹哌嗪诱导的运动活性主要涉及多巴胺能机制，5-HT在刺激此行为中要么不发挥作用，要么起辅助作用，其表达需要完整的中枢多巴胺能受体。
