A method for induction of cold, indomethacin and restraint ulcers in rats.

A new method has been developed for producing gastric ulcers in rats. The rapid induction of gastric lesions was achieved by a combination of the administration of indomethacin in addition to cold and restraint stressors. Ulcer indices were easily reproducible and remained constant. In addition, atropine, cimetidine and an antacid were tested for their antiulcerogenic effects with the same model. All three drugs inhibited ulcer development in a dose-dependent manner.