Seccia A, Farallo E
Minerva Med. 1978 May 19;69(25):1731-8.
A series of over 300 cases of highly malignant basal and prickle-cell epitheliomas is presented as an illustration of the way in which due importance is not always given to forms that may well be deeply invasive, though these are only some of the epitheliomas that may be encountered. The particular nature of each formation is not always evident at first and may be the cause of its further progression. High malignancy is more common in cases of recurrence and poor management, so that ineffective attempts at treatment may be seen as a contributing factor. Of course, when treatment has been correct, failure and subsequent recurrence may point to primary "predisposition" to recur; this tendency cannot yet be detected in time or with precision. Local malignancy is often independent of the type of epithelioma involved. Indeed, it is more serious and difficult to combat in the case of basal cell forms on first recurrence and resistance to proper management, whereas in prickle-cell epithelioma, when distant metastasis is prevented, local invasiveness is frequently conquered by truly radical surgery.
本文呈现了300多例高恶性基底细胞和棘细胞上皮瘤病例，以说明这样一种情况：对于那些很可能具有深层浸润性的肿瘤形式，人们并非总是给予应有的重视，尽管这些只是可能遇到的上皮瘤中的一部分。每种肿瘤的特殊性质起初并不总是明显的，这可能是其进一步发展的原因。高恶性在复发和治疗不当的病例中更为常见，因此无效的治疗尝试可能被视为一个促成因素。当然，当治疗正确时，治疗失败及随后的复发可能表明存在原发性复发“易感性”；这种倾向目前还无法及时准确地检测出来。局部恶性程度往往与所涉及的上皮瘤类型无关。实际上，在基底细胞型首次复发且对适当治疗有抵抗时，局部恶性更为严重且更难对抗，而在棘细胞上皮瘤中，当防止远处转移时，真正的根治性手术常常能战胜局部浸润性。
