Salgarello M, Seccia A, Sturla M, Bracaglia R, Loreti A, Vricella M, Farallo E
Department of Plastic Surgery, Università Cattolica del Sacro Cuore, Roma, Italy.
J Otolaryngol. 1998 Oct;27(5):288-92.
Epitheliomas of the nose are frequently highly aggressive lesions with wide cutaneous-subcutaneous growth or an infiltrative growth pattern, especially when located at the columellar base, the alar base, and toward the inner chantal region. The aim of this study was to review this lesion with respect to location, recurrence, and treatment.
The authors present a retrospective study of 193 infiltrating epitheliomas of the nose examined between 1986 and 1995, including primary and recurrent cases. The authors term "clinically infiltrating epithelioma" any epithelioma whose growth implies the infiltration of the osteocartilaginous framework.
The analysis of this case series, based on the histotype and the site of the epitheliomas, confirms that most of the primary histologically infiltrating basal cell carcinomas (BCCs) and of the recurrent BCCs are located at the alar base. The analysis of recurrences shows an aggressive local behaviour (multiple recurrences in the same site, change of the histologic pattern toward a more malignant one, etc.) suggesting that many of them were submitted to an insufficient physical or surgical treatment in the past.
A radical surgical approach at the first signs of the primary lesion is mandatory in cases of nasal epithelioma.
鼻部上皮瘤通常是具有广泛皮肤-皮下生长或浸润性生长模式的高度侵袭性病变，尤其是位于鼻小柱基部、鼻翼基部以及朝向鼻内眦区域时。本研究的目的是就该病变的位置、复发情况及治疗进行综述。
作者对1986年至1995年间检查的193例鼻部浸润性上皮瘤进行了回顾性研究，包括原发性和复发性病例。作者将任何生长涉及骨软骨框架浸润的上皮瘤称为“临床浸润性上皮瘤”。
基于上皮瘤的组织学类型和部位对该病例系列进行的分析证实，大多数原发性组织学浸润性基底细胞癌（BCC）和复发性BCC位于鼻翼基部。对复发情况的分析显示出侵袭性的局部行为（同一部位多次复发、组织学模式向更恶性的方向转变等），这表明它们中的许多在过去接受了不充分的物理或手术治疗。
对于鼻部上皮瘤病例，在原发性病变出现最初迹象时采取根治性手术方法是必要的。
