Zaleska-Freljan K I, Kosicka B, Zbiegieni B
Pol J Pharmacol Pharm. 1983 May-Jun;35(3):185-93.
Bromfenvinphos (0.0-diethyl-0-1-(2.4-dichlorphenyl)-2-bromvinyl phosphate), BrV, 12.33 mg/kg/day, alone and in combination with methoxychlor ( (1,1,1-trichlor-2.2-)4-methoxyphenyl ethane), MeOCl, 24.66 mg/kg/day, were administered to laboratory mice in the olive-oil suspension through the stomach gauge once a day for 6 weeks. The histological changes developed in liver and kidneys of mice were investigated. BrV and BrV + MeOCl caused the hyperemia and fine-grained inflammatory infiltration in liver tissue. The small histological changes were observed in kidneys of animals which received the pesticides: the stellate shape lumen of the proximal convoluted kidney tubules and the vacuolar degeneration changes in the wall cells of these tubules. There occurred degeneration changes in the wall cells of these tubules. No pathological changes appeared in stomach, small and large intestine, heart, spleen and in gonads of the experimental mice.
溴苯磷（0.0 - 二乙基 - 0 - 1 - （2,4 - 二氯苯基）- 2 - 溴乙烯基磷酸酯），简称BrV，剂量为12.33毫克/千克/天，以及与甲氧滴滴涕（（1,1,1 - 三氯 - 2,2 - ）4 - 甲氧基苯基乙烷），简称MeOCl，剂量为24.66毫克/千克/天，以橄榄油悬浮液的形式通过胃管每日一次给实验小鼠给药，持续6周。对小鼠肝脏和肾脏发生的组织学变化进行了研究。BrV和BrV + MeOCl导致肝脏组织充血和细颗粒状炎性浸润。在接受农药处理的动物肾脏中观察到微小的组织学变化：近端曲管的星状管腔以及这些肾小管壁细胞中的空泡变性变化。这些肾小管的壁细胞出现了变性变化。实验小鼠的胃、小肠、大肠、心脏、脾脏和性腺未出现病理变化。
