Zaleska-Freljan K I, Wolewicz J T
Department of Vertebrate Animal Physiology, University of Warsaw, Poland.
Pol J Pharmacol. 1993 May-Jun;45(3):309-16.
Bromfenvinphos [0,0-diethyl-1-(2,4-dichlorophenyl)-2-bromovinyl phosphate], (BrV), 12.33 mg/kg/day alone and in combination with methoxychlor [1,1,1-trichloro-2,2-bis(4-methoxyphenyl)ethane], (MeOCl), 24.66 mg/kg/day were administered daily per os (intragastrically) in pure olive-oil for 6 weeks to male laboratory mice. The activity of gamma-glutamyl transpeptidase (GGTP), ceruloplasmin (CRP), and cholesterol in the blood plasma were determined. The hematocrit value, the erythrocyte count and the weights of the liver, spleen, heart, kidney and gonads were also measured after the end of treatment. BrV and BrV + MeOCl increased the activity of gamma-glutamyl transpeptidase. The activity of ceruloplasmin and the level of cholesterol in the blood plasma as well as the erythrocyte count in the blood were also similar in the control and experimental mice. The hematocrit value decreased after BrV and MeOCl administration. The relative weight of liver was higher in mice receiving both drugs in combination, than in control and in mice receiving BrV alone. The relative weight of spleen was significantly higher in animals receiving BrV alone, than in other groups.
将溴苯磷[0,0 - 二乙基 - 1 - (2,4 - 二氯苯基)-2 - 溴乙烯基磷酸酯]（BrV），单独以12.33毫克/千克/天的剂量以及与甲氧滴滴涕[1,1,1 - 三氯 - 2,2 - 双(4 - 甲氧基苯基)乙烷]（MeOCl）以24.66毫克/千克/天的剂量组合，每日经口（胃内）用纯橄榄油给予雄性实验小鼠，持续6周。测定血浆中γ - 谷氨酰转肽酶（GGTP）、铜蓝蛋白（CRP）的活性以及胆固醇水平。在治疗结束后还测量了血细胞比容值、红细胞计数以及肝脏、脾脏、心脏、肾脏和性腺的重量。BrV以及BrV + MeOCl增加了γ - 谷氨酰转肽酶的活性。对照组和实验组小鼠血浆中铜蓝蛋白的活性、胆固醇水平以及血液中的红细胞计数也相似。给予BrV和MeOCl后血细胞比容值降低。联合接受两种药物的小鼠肝脏相对重量高于对照组以及单独接受BrV的小鼠。单独接受BrV的动物脾脏相对重量显著高于其他组。
