Strauss J H, Wilson M, Caldwell D, Otterson W, Martin A O
Am J Obstet Gynecol. 1979 Jun 1;134(3):260-4. doi: 10.1016/s0002-9378(16)33030-7.
A laminaria tent was used as an adjunct during midtrimester abortion to attempt to shorten the injection-abortion interval without adversely affecting the frequency of infection, hemorrhage, failed abortion, or cervical laceration. Eighty patients, between 14 and 20 weeks' gestation and desiring pregnancy termination, were randomized into three groups. Abortion was initiated by an intra-amniotic infusion of 20 mg of prostaglandin F2alpha and 80 gm of hyperosmolar urea in Ringer's lactate (135 ml total volume), followed by oxytocin infused intravenously at 333 mU/min. Group I (N = 28) received no additional therapy; Group II (N = 23) had laminaria placed at the time of the abortifacient injection and removed 4 hours later; Group III (N = 29) had laminaria placed 4 hours prior to inejction and removed at the time of injection. The injection-abortion intervals in these three groups were 17.76, 20.80, and 12.96 hours, respectively. This study illustrates that a laminaria tent palced 4 hours prior to injection is significantly more effective than a laminaria tent placed at the time of injection, and produces a shorter mean injection-abortion interval than that in patients receiving no laminaria. Furthermore, laminaria augmentation results in no demonstrable increase in the frequency of serious complications.
在孕中期流产过程中，使用海藻棒作为辅助手段，试图缩短注射流产的间隔时间，同时不影响感染、出血、流产失败或宫颈裂伤的发生率。80例妊娠14至20周且希望终止妊娠的患者被随机分为三组。流产通过羊膜腔内注入20毫克前列腺素F2α和80克高渗尿素于乳酸林格液中（总体积135毫升）启动，随后静脉滴注催产素，速度为333毫单位/分钟。第一组（N = 28）未接受额外治疗；第二组（N = 23）在注射堕胎药时放置海藻棒，4小时后取出；第三组（N = 29）在注射前4小时放置海藻棒，注射时取出。这三组的注射流产间隔时间分别为17.76小时、20.80小时和12.96小时。本研究表明，在注射前4小时放置海藻棒比在注射时放置海藻棒显著更有效，且平均注射流产间隔时间比未使用海藻棒的患者更短。此外，使用海藻棒并未导致严重并发症的发生率明显增加。
