健康志愿者注射碘海醇后的耐受性

Tolerability of iohexol after injection into healthy volunteers.

作者信息

Levorstad K, Kolbenstvedt A, Kolmannskog F, Sommerfelt S C, Stormorken H, Andrew E, Sveen K

出版信息

Acta Radiol Diagn (Stockh). 1983;24(3):241-51. doi: 10.1177/028418518302400311.

Abstract

The effects of iohexol, a new non-ionic contrast medium, after intravenous injection into humans are reported. After injection of small doses into 2 subjects, iohexol was injected intravenously into 20 healthy male volunteers in doses of 125 to 500 mg I/kg body weight. A large number of physiologic, biochemical, hematologic and pharmacokinetic parameters were analysed. The results indicated that iohexol was well tolerated and that clinical trials in patients could be undertaken.

摘要

本文报道了新型非离子型造影剂碘海醇静脉注射入人体后的效应。向2名受试者注射小剂量碘海醇后，以125至500毫克碘/千克体重的剂量将碘海醇静脉注射入20名健康男性志愿者体内。分析了大量生理、生化、血液学和药代动力学参数。结果表明，碘海醇耐受性良好，可以对患者进行临床试验。