Hagberg J M, Goldring D, Ehsani A A, Heath G W, Hernandez A, Schechtman K, Holloszy J O
Am J Cardiol. 1983 Oct 1;52(7):763-8. doi: 10.1016/0002-9149(83)90412-5.
Twenty-five adolescents (aged 16 +/- 1 years) whose blood pressure (BP) was persistently above the 95th percentile for their age and sex were studied before and after 6 +/- 1 months of exercise training and again 9 +/- 1 months after the cessation of training. Maximal oxygen consumption (VO2) increased significantly with training. There was no change in body weight or sum of skinfolds. Both systolic and diastolic BP decreased significantly with training; however, complete BP normalization was not achieved. When the subjects were retested 9 +/- 1 months after cessation of training, systolic BP and VO2 max had returned to pretraining levels; however, diastolic BP was still below pretraining levels in the subjects who had diastolic hypertension initially. Except in subjects who initially had an elevated cardiac output, no consistent hemodynamic changes were found with training or cessation of training to account for the reductions in BP. The subjects whose resting cardiac outputs were high initially had significantly lower cardiac outputs after training as a result of decreases in both heart rate and stroke volume; however, vascular resistance remained unchanged. Sedentary control subjects with similar BP had no significant change in any of the variables measured over a similar period. These data indicate that moderate endurance exercise training can lower BP in otherwise healthy hypertensive adolescents as an initial therapeutic intervention.
对25名青少年（年龄16±1岁）进行了研究，他们的血压持续高于其年龄和性别的第95百分位数，在进行6±1个月的运动训练前后以及训练停止后9±1个月再次进行研究。最大耗氧量（VO2）随着训练显著增加。体重和皮褶厚度总和没有变化。收缩压和舒张压都随着训练显著降低；然而，血压并未完全恢复正常。当在训练停止后9±1个月对受试者进行重新测试时，收缩压和最大VO2已恢复到训练前水平；然而，最初患有舒张期高血压的受试者的舒张压仍低于训练前水平。除了最初心输出量升高的受试者外，未发现训练或训练停止后有一致的血流动力学变化来解释血压的降低。最初静息心输出量高的受试者在训练后由于心率和每搏输出量的降低，心输出量显著降低；然而，血管阻力保持不变。血压相似的久坐不动的对照受试者在相似时间段内测量的任何变量均无显著变化。这些数据表明，适度的耐力运动训练作为初始治疗干预措施，可以降低原本健康的高血压青少年的血压。
