Legrand S, Meisel C, Legrand J C
Ann Med Interne (Paris). 1983;134(3):227-9.
The conditions which must be respected to ensure the validity of the biochemical diagnostic criteria of primary hyperaldosteronism, conditions of blood sampling, timing posture and age of the patient, sodium intake and intercurrent drug therapy. As none of the tests is 100 p. 100 specific in distinguishing adrenal adenoma from hyperplasia, an association of several investigations has to be used. In cases of adenoma, the authors recommend the investigations which demonstrate the autonomy of secretion and the prevalence of circadian rhythm over the influence of change in posture. The measurement of aldosterone levels may be completed by that of its precursor, 18-hydroxy-corticosterone (18 OH CS).
为确保原发性醛固酮增多症生化诊断标准的有效性，必须遵守一些条件，包括血样采集条件、患者的体位、时间及年龄、钠摄入量以及并发药物治疗情况。由于没有一项检测在区分肾上腺腺瘤与增生方面具有100%的特异性，因此必须综合多项检查结果。对于腺瘤病例，作者推荐进行能证明分泌自主性以及昼夜节律相对于体位变化影响的优势的检查。醛固酮水平的测量可通过其前体18-羟皮质酮（18 OH CS）的测量来补充。
