Thibonnier M, Plouin P F, Ménard J, Corvol P
Ann Med Interne (Paris). 1983;134(3):251-5.
The diagnosis of primary tumoral hyperaldosteronism is based on a series of hormonal parameters, measured under resting conditions and after stimulation. The results of the administration of a single dose of a converting enzyme inhibitor, Captopril (1 mg/kg body weight per os), can support this diagnosis. In contrast to essential hypertension and hyperaldosteronism due to bilateral adrenal hyperplasia, plasma aldosterone levels remain unchanged in tumoral hyperaldosteronism after administrating Captopril. This is a simple test which can be performed in a morning which clearly differentiated 8 cases of primary tumoral hyperaldosteronism from 6 cases of adrenal hyperplasia.
原发性肿瘤性醛固酮增多症的诊断基于一系列在静息状态下及刺激后测量的激素参数。单剂量给予转换酶抑制剂卡托普利（口服1mg/kg体重）的结果可支持这一诊断。与原发性高血压及双侧肾上腺增生所致醛固酮增多症不同，在给予卡托普利后，肿瘤性醛固酮增多症患者的血浆醛固酮水平保持不变。这是一项简单的检查，可在上午进行，能明确将8例原发性肿瘤性醛固酮增多症与6例肾上腺增生区分开来。
