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[从菌丝体中用二甲基亚砜提取制霉菌素]

[Dimethyl sulfoxide extraction of nystatin from mycelium].

作者信息

Maĭdanov V V, Egutkin N L, Nikitin Iu E

出版信息

Antibiotiki. 1983 Jul;28(7):502-4.

PMID:6625545
Abstract

Solubility of nystatin in dimethylsulfoxide (DMSO) and its water solutions was studied. It was found that the capacity of DMSO with respect to nystatin was at least 40 times higher than that of the known extracting agents. DMSO is recommended for extraction of nystatin from dry mycelium. The optimal conditions for extraction of nystatin and its recovery from the extract phases were determined. Nystatin isolated with this method meets the specification requirements.

摘要

研究了制霉菌素在二甲基亚砜（DMSO）及其水溶液中的溶解度。发现DMSO对制霉菌素的溶解能力至少比已知萃取剂高40倍。推荐使用DMSO从干菌丝体中提取制霉菌素。确定了从萃取相中提取制霉菌素及其回收的最佳条件。用该方法分离得到的制霉菌素符合规格要求。

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