Musch D C, Sugar A, Meyer R F
Arch Ophthalmol. 1983 Oct;101(10):1545-8. doi: 10.1001/archopht.1983.01040020547007.
We identified 224 patients hospitalized with corneal ulcerations at the University of Michigan Hospitals, Ann Arbor, between May 1975 and September 1981, and performed a chart review on a random sample of these cases. Bimodality in the patients' age distribution was attributed to nonsurgical ocular trauma in the younger group, and predisposing keratitis, surgical trauma, bullous keratopathy, and entropion in the older group. Bacterial and postherpetic causes accounted for 52 (52%) of the sampled cases. Pseudomonas aeruginosa and Staphylococcus aureus were the major isolates. Important predisposing factors included nonsurgical and surgical trauma, herpetic keratitis, contact lens wear, corticosteroid therapy, and bullous keratopathy. Both age and visual acuity on admission had prognostic implications for improvement in visual acuity after treatment.
1975年5月至1981年9月期间，我们在密歇根大学安娜堡分校医院确定了224例因角膜溃疡住院的患者，并对这些病例的随机样本进行了病历审查。患者年龄分布的双峰现象归因于较年轻组的非手术性眼外伤，以及较年长组的易患性角膜炎、手术创伤、大泡性角膜病变和睑内翻。细菌和疱疹后病因占抽样病例的52例（52%）。铜绿假单胞菌和金黄色葡萄球菌是主要的分离菌株。重要的诱发因素包括非手术和手术创伤、疱疹性角膜炎、隐形眼镜佩戴、皮质类固醇治疗和大泡性角膜病变。年龄和入院时的视力对治疗后视力的改善均有预后意义。
