硝苯地平作为雷诺现象的一种治疗方式。

Nifedipine as a therapeutic modality for Raynaud's phenomenon.

作者信息

Winston E L, Pariser K M, Miller K B, Salem D N, Creager M A

出版信息

Arthritis Rheum. 1983 Oct;26(10):1177-80. doi: 10.1002/art.1780261001.

Abstract

Eight patients with Raynaud's phenomenon were entered into a double-blind crossover study of nifedipine versus placebo, with 7 patients undergoing finger plethysmography before and after sublingual nifedipine administration. While receiving nifedipine, all patients reported decreased frequency and severity of attacks, and 4 of 5 had digital ulcer healing. Total finger blood flow increased 5 of 6 patients after treatment with sublingual nifedipine. This preliminary study indicates that nifedipine may be a useful agent for treatment of digital vasospasm.

摘要

八名患有雷诺现象的患者进入了硝苯地平与安慰剂的双盲交叉研究，其中7名患者在舌下给予硝苯地平前后接受了手指体积描记法检查。在服用硝苯地平期间，所有患者均报告发作频率和严重程度降低，5名患者中有4名出现指端溃疡愈合。舌下给予硝苯地平治疗后，6名患者中有5名的手指总血流量增加。这项初步研究表明，硝苯地平可能是治疗指端血管痉挛的有效药物。