杜氏肌营养不良症：淋巴细胞流动性的改变。
Duchenne muscular dystrophy: alterations in lymphocyte fluidity.
作者信息
Ferretti G, Falcioni A M, Curatola G, Valentini B, Saccucci F
出版信息
Boll Soc Ital Biol Sper. 1983 Jul 30;59(7):1035-40.
PMID:6626329
Abstract
We have studied lymphocyte membrane from 7 patients with Duchenne Muscular Dystrophy (DMD) and 8 normal controls using fluorescence polarization of 1,6-diphenyl-hexatriene (DPH). The microviscosity of lymphocytes membrane is significatively higher in DMD patients than in normal controls. Our results support the hypothesis of a generalized membrane defect in Duchenne Muscular Dystrophy.
摘要
我们使用1,6 - 二苯基 - 己三烯（DPH）的荧光偏振技术，对7例杜氏肌营养不良症（DMD）患者和8名正常对照者的淋巴细胞膜进行了研究。DMD患者淋巴细胞膜的微粘度显著高于正常对照者。我们的结果支持杜氏肌营养不良症存在全身性膜缺陷这一假说。
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