Bettini V, Gamba G, Legrenzi E, Libardoni C, Mayellaro F
Boll Soc Ital Biol Sper. 1983 Aug 30;59(8):1064-9.
The aim of this work is to study the mechanism by which 4-metilesculetin (4-Me) cause the relaxation or inhibit the serotonin induced contraction in the smooth muscle. The effect of 4-Me, alone or associated with ascorbic-acid, on basal tone and serotonin induced contraction of isolated coronary strips have been studied. Experiments have been carried out in the presence of indomethacin (IN), specific inhibitor of prostaglandin synthetase. IN-decreased, but did not abolished, the 4-Me induced relaxation and reduced or suppressed the depressive effect of 4-Me on the serotonin dependent contraction. Therefore, it seems reasonable to conclude that the 4-Me influence could be mediated by prostaglandins release in the smooth muscle.
本研究旨在探讨4-甲基伞形酮（4-Me）引起平滑肌舒张或抑制5-羟色胺诱导的收缩的机制。研究了4-Me单独或与抗坏血酸联合使用对离体冠状动脉条基础张力和5-羟色胺诱导收缩的影响。实验在前列腺素合成酶特异性抑制剂吲哚美辛（IN）存在的情况下进行。IN可降低但不能消除4-Me诱导的舒张，并降低或抑制4-Me对5-羟色胺依赖性收缩的抑制作用。因此，有理由得出结论，4-Me的影响可能是通过平滑肌中前列腺素的释放介导的。
