血浆地高辛：经Fab治疗患者的检测异常
Plasma digoxin: assay anomalies in Fab-treated patients.
作者信息
Gibb I, Adams P C, Parnham A J, Jennings K
出版信息
Br J Clin Pharmacol. 1983 Oct;16(4):445-7. doi: 10.1111/j.1365-2125.1983.tb02194.x.
Abstract
Using a variety of radioimmunoassay methods, plasma digoxin concentrations were measured in two patients before and after the administration of ovine Fab antibody fragments to remove the effects of digoxin. Gross method-dependent anomalies in the results due to in vitro drug interaction were observed. More widespread use of immunotherapy may invalidate data obtained by direct immunoassay techniques.
摘要
使用多种放射免疫测定方法，在两名患者中测定了给予羊源Fab抗体片段以消除地高辛影响前后的血浆地高辛浓度。观察到由于体外药物相互作用导致结果中存在明显的方法依赖性异常。免疫疗法的更广泛应用可能会使通过直接免疫测定技术获得的数据无效。
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N Engl J Med. 1971 May 6;284(18):989-97. doi: 10.1056/NEJM197105062841801.
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